Ciclosporine A eye drops for vernal!

The RCT published in Ophthalmology ( showed significant quality of life and corneal fluoresceine staining score improvement in those patients with vernal keratoconjunctivitis treated with Ciclosporine A cationic emulsion 4 times daily in comparison with CsA CE 2x daily or placebo.

Useful findings. Vernal and atopic keratoconjunctivitides comprase a major burden in Sub-Saharan Africa, and the usual steroid medications bring not only the temporary relief, but also complications (steroid cataract and steroid glaucoma, not a pleasant thing in the very young age of those patients…).

The results were not a surprise. However, the other major difficukty in those countries is the availability and the cost of such eye drops. Both ciclosporin and f.e. tacrolimus are very not easy to procure.